First of December. World AIDS Day : a time to stop in
medical advances to combat the disease. 35 million people are suffering AIDS in
the world, among them more than 25 million are in Africa. Therapies slow down the
progression of this disease, but are expensive and long time toxicity .
Px Therapeutics scientists searching a vaccine against
AIDS. The 41 Euroneut program involving 17 European partners investigates how
to block entry of the virus into the body.
The vaccine is based on the gp41 protein which is
within the virus .
Nicolas Mouz is the director of Px Therapeutics, in
Grenoble , France: " The GP41 protein was chosen because it is a protein
that is located on the surface of the virus. Is a protein that the immune system
can sense and also plays a important role in the mechanism of virus entry into
the cell. " The AIDS virus is
constantly changing to fool our immune system. But the GP41 protein does not
change, what could be the Achilles heel of the virus. If the body produces
neutralizing antibodies, the vaccine could be effective .
In the UK, the Guilford Center conducts tests on
volunteer patients . Dr. David Lewis , medical immunologist , is responsible
for the investigation of this vaccine. The Doctor Lewis says: "If we put
the vaccine in the nose a good response in the genital tract is stimulated. So
the concept is innovative start administering the vaccine in the nose with 3
doses . This prepares the body for a good response in the genital tract in
order to block infection with antibodies to keep it out . "
The human immunodeficiency virus is so complex that
you have to combine all the preventive measures from access to antiretrovirals
to achieve a safe and effective vaccine.
Informative Video: New Hopes for an AIDS Vaccine